UTP metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the UTP metabolic process pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher UTP metabolic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and READ, show the opposite pattern, with higher activity associated with better survival.

KIRP, BRCA, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.502	0.828	<.001	64	view →
BRCA	OS	Median	IV	0.839	0.298	<.001	50	view →
MESO	DFS	Quartile	II,III,IV	0.281	0.519	.011	46	view →
LIHC	OS	Tertile	All	0.574	0.753	.002	34	view →
ACC	OS	Tertile	II,III,IV	0.332	0.847	.015	31	view →
READ	DFS	Tertile	All	0.935	0.727	.007	24	view →
BLCA	OS	Quartile	All	0.641	0.812	.006	19	view →
SARC	OS	Quartile	All	0.742	0.918	<.001	19	view →
LGG	DFS	Quartile	All	0.310	0.488	<.001	16	view →
THCA	DFS	Median	All	0.680	0.870	.013	16	view →
UCS	OS	Tertile	IV	0.773	0.303	.017	12	view →
THYM	DFS	Tertile	All	0.591	0.846	.015	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0046051–KIRP (DFS)

Open the KIRP breakdown →