UTP metabolic process

Across TCGA cell cohorts, RNA activity of the UTP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR75, RCL1, and METTL21A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UTP metabolic process activity versus WDR75 in PANCREAS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	WDR75 →	+0.819	+0.352	<.001	<.001	3	6
BONE	RCL1 →	+1.391	+0.401	.003	<.001	3	6
PANCREAS	METTL21A →	+0.884	+0.393	<.001	.003	3	6
LUNG_NSCLC_LUSC	CRACD →	+1.273	+0.428	.006	.002	3	6
LIVER	FAM136A →	+1.229	+0.366	.006	.001	3	6
UPPER_AERODIGESTIVE_TRACT	PARP1 →	+0.912	+0.676	.006	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046051 vs WDR75 — PANCREAS

Explore this scatter interactively →