UMP catabolic process

Across TCGA patient cohorts, RNA activity of the UMP catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UPP1, AHNAK2_S260, and IKBIP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UMP catabolic process activity versus UPP1 in GBM (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UPP1 →	+0.837	+0.114	<.001	<.001	3	8
LSCC	AHNAK2_S260 →	+1.148	+0.086	<.001	.003	3	7
GBM	IKBIP →	+0.651	+0.109	<.001	<.001	3	6
BRCA	LDHA →	+0.390	+0.060	.001	.008	3	6
GBM	RPRD2_T723 →	-0.454	-0.079	.002	.008	3	6
OV	SLC16A3 →	+0.519	+0.062	.003	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046050 vs UPP1 — GBM

Explore this scatter interactively →