CMP metabolic process

Across TCGA patient cohorts, RNA activity of the CMP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UPP1, SSH1_S834, and LOXL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CMP metabolic process activity versus UPP1 in OV (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	UPP1 →	+0.529	+0.056	<.001	<.001	3	5
UCEC	SSH1_S834 →	+1.063	+0.137	<.001	.001	3	5
COAD	LOXL2 →	+0.351	+0.035	<.001	<.001	3	5
BRCA	ZBTB37_S310 →	-0.504	-0.053	.001	.001	3	5
LUAD	GPD1L →	-0.271	-0.036	.009	.005	2	6
OV	SAMSN1_S23 →	+0.859	+0.075	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046035 vs UPP1 — OV

Explore this scatter interactively →