CMP metabolic process

Across TCGA patient cohorts, RNA activity of the CMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WARS1, GMFG, and MS4A6A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CMP metabolic process activity versus WARS1 in HNSC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	WARS1 →	+0.845	+0.104	.001	.006	3	6
BRCA	GMFG →	+0.642	+0.157	.001	.004	3	6
LUAD	MS4A6A →	+0.463	+0.200	.003	.001	3	5
HNSC	CD86 →	+0.683	+0.157	.002	<.001	3	5
LUAD	STAT1 →	+0.489	+0.172	.003	.002	3	5
BRCA	CD72 →	+0.445	+0.130	.005	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046035 vs WARS1 — HNSC

Explore this scatter interactively →