CMP metabolic process

Across TCGA cell cohorts, RNA activity of the CMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAT1, TCF4, and AKR7A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADAT1 grouped by CMP metabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ADAT1 →	+1.039	+1.424	.001	.004	3	4
LUNG_NSCLC_LUSC	TCF4 →	+3.914	+1.572	.001	.002	3	4
LUNG_NSCLC_LUAD	AKR7A3 →	+0.947	+0.695	.005	<.001	3	3
LIVER	SMARCA2 →	+1.457	+0.504	<.001	.006	3	3
CNS	KITLG →	+1.604	+0.899	<.001	.004	3	3
BLOOD_Myeloma	CCDC189 →	+1.372	+2.063	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADAT1 by CMP metabolic process activity — LIVER

Explore this box plot interactively →