ATP metabolic process

Across TCGA cell cohorts, RNA activity of the ATP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASXL2, PPP4R3B, and NFKB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ASXL2 grouped by ATP metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASXL2 →	-0.661	-0.215	.003	.001	3	5
LUNG_NSCLC_LUSC	PPP4R3B →	-0.742	-0.194	.002	.003	3	4
LUNG_NSCLC_LUAD	NFKB1 →	-0.683	-0.279	.001	.005	3	4
LUNG_SCLC	UBL7 →	-0.503	-0.227	.001	.001	3	4
LARGE_INTESTINE	ZBED6 →	-0.654	-0.143	.003	.003	3	4
BREAST	CDH2 →	-1.578	-0.178	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ASXL2 by ATP metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →