AMP metabolic process

Across TCGA patient cohorts, RNA activity of the AMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F13A1, RUNX2, and GIMAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AMP metabolic process activity versus F13A1 in GBM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	F13A1 →	+1.840	+0.128	<.001	<.001	3	5
PDAC	RUNX2 →	+0.564	+0.152	.002	.004	3	5
BRCA	GIMAP1 →	+0.524	+0.186	<.001	<.001	3	5
GBM	TNFSF12 →	+0.303	+0.112	.001	.001	3	5
OV	TDO2 →	+1.191	+0.150	.002	.003	3	4
OV	MMP1 →	+1.426	+0.217	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046033 vs F13A1 — GBM

Explore this scatter interactively →