ADP metabolic process

Across TCGA patient cohorts, RNA activity of the ADP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AK4, NT5E, and CENPC, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ADP metabolic process activity versus AK4 in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AK4 →	+0.824	+0.079	<.001	<.001	3	8
GBM	NT5E →	+0.660	+0.090	.002	<.001	2	7
BRCA	CENPC →	-0.237	-0.047	.004	.005	2	6
UCEC	HUWE1_S1907 →	-0.340	-0.067	<.001	.003	3	5
LUAD	PREPL →	+0.256	+0.064	<.001	.001	3	5
BRCA	CLP1 →	-0.198	-0.051	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046031 vs AK4 — BRCA

Explore this scatter interactively →