ADP metabolic process

Across TCGA cell cohorts, RNA activity of the ADP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2A, CCDC25, and MESP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ADP metabolic process activity versus EIF2A in LUNG_NSCLC_LUSC (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	EIF2A →	-0.727	-0.278	<.001	.008	3	5
LUNG_NSCLC_LUSC	CCDC25 →	+0.962	+0.269	<.001	.001	3	5
OESOPHAGUS	MESP1 →	+0.664	+0.206	.002	.005	3	5
LARGE_INTESTINE	PPL →	-1.353	-0.163	.006	.003	3	5
URINARY_TRACT	HERC4 →	+0.958	+0.400	.001	.004	3	5
LUNG_NSCLC_LUAD	AK3 →	+0.881	+0.235	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046031 vs EIF2A — LUNG_NSCLC_LUSC

Explore this scatter interactively →