Positive regulation of transcription by glucose

Across TCGA patient cohorts, RNA activity of the Positive regulation of transcription by glucose pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35E1P1, G2E3, and ZNF701, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription by glucose activity versus SLC35E1P1 in LSCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC35E1P1 →	+0.460	+0.685	<.001	<.001	3	3
UCEC	G2E3 →	-0.419	-0.815	<.001	<.001	3	3
GBM	ZNF701 →	+0.289	+0.643	.001	<.001	3	3
GBM	MFSD14C →	+0.341	+0.461	.003	.008	3	3
GBM	ZNF568 →	+0.344	+0.551	.003	.001	3	3
GBM	PTMAP1 →	+0.470	+0.521	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046016 vs SLC35E1P1 — LSCC

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