Positive regulation of transcription by glucose

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of transcription by glucose pathway differs between tumor and matched normal tissue in 16 of the 18 cancer types tested.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRP and LUSC, show the opposite pattern, with lower activity in tumor tissue.

KIRP, COAD, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRP	All	II,III,IV	−0.121	<.001	11	view →
COAD	All	IV	+0.115	<.001	11	view →
LUSC	Female	II,III,IV	−0.194	<.001	9	view →
LUAD	Female	III,IV	−0.147	<.001	9	view →
HNSC	Male	All	−0.101	<.001	8	view →
BLCA	All	All	−0.070	<.001	8	view →
BRCA	All	III,IV	−0.092	<.001	6	view →
UCEC	All	All	−0.087	<.001	6	view →
KICH	All	All	−0.053	.001	6	view →
STAD	Male	All	−0.080	<.001	5	view →
KIRC	Female	All	−0.071	<.001	5	view →
THCA	All	All	−0.040	.002	4	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 16 lineages.

GO:0046016–KIRP

Open the KIRP breakdown →