Negative regulation of activated T cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of activated T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOSC4, CYC1, and PPP1R16A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of activated T cell proliferation activity versus EXOSC4 in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EXOSC4 →	+0.978	+0.782	<.001	<.001	3	5
BRCA	CYC1 →	+0.930	+0.876	<.001	<.001	3	5
BRCA	PPP1R16A →	+0.789	+0.534	.006	.003	2	5
BRCA	SHARPIN →	+0.870	+0.694	<.001	.001	2	5
BRCA	PUF60 →	+1.097	+0.802	<.001	<.001	3	4
BRCA	IQANK1 →	+0.471	+0.471	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046007 vs EXOSC4 — BRCA

Explore this scatter interactively →