Negative regulation of activated T cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of activated T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCAF5, ZNF668, and RABEP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DCAF5 grouped by Negative regulation of activated T cell proliferation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DCAF5 →	+0.770	+1.498	.007	.008	3	4
SKIN	ZNF668 →	-0.343	-0.786	.004	.007	3	4
SKIN	RABEP2 →	-0.610	-0.878	.002	.002	3	4
BLOOD_Lymphoma	RASA2 →	+1.092	+1.838	.003	<.001	3	4
BLOOD_Lymphoma	ZNF773 →	+1.450	+1.814	.002	<.001	2	5
BREAST	DDX50 →	+0.443	+0.925	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DCAF5 by Negative regulation of activated T cell proliferation activity — URINARY_TRACT

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