Negative regulation of activated T cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of activated T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTL8A, IQSEC2, and USP27X, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of activated T cell proliferation activity versus RTL8A in SOFT_TISSUE (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RTL8A →	+1.227	+0.241	.007	<.001	3	5
SOFT_TISSUE	IQSEC2 →	+1.438	+0.245	.004	<.001	3	4
SOFT_TISSUE	USP27X →	+0.746	+0.220	.001	.002	3	4
CNS	RNH1 →	+0.718	+0.265	.006	<.001	3	4
LUNG_SCLC	TLE5 →	+1.267	+0.302	.001	.001	3	4
LUNG_NSCLC_LUAD	OPRL1 →	+0.745	+0.521	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046007 vs RTL8A — SOFT_TISSUE

Explore this scatter interactively →