Regulation of embryonic development

Across TCGA cell cohorts, RNA activity of the Regulation of embryonic development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STMN1, TTF1, and SOAT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of embryonic development activity versus STMN1 in LUNG_NSCLC_LUAD (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	STMN1 →	+0.872	+0.136	.001	.005	3	6
PANCREAS	TTF1 →	+0.621	+0.307	.001	.001	3	6
LARGE_INTESTINE	SOAT1 →	+1.694	+0.163	<.001	.002	3	5
BLOOD_Leukemia	ZNF510 →	+0.786	+0.123	<.001	.001	3	5
OESOPHAGUS	NRGN →	+1.815	+0.192	.002	.003	2	6
SOFT_TISSUE	ODF2 →	+1.028	+0.254	.002	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045995 vs STMN1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →