Carbon catabolite regulation of transcription

Across TCGA cell cohorts, RNA activity of the Carbon catabolite regulation of transcription pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WASF1, ZNF709, and PSIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbon catabolite regulation of transcription activity versus WASF1 in LARGE_INTESTINE (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WASF1 →	+1.105	+0.377	.002	<.001	3	5
BLOOD_Leukemia	ZNF709 →	+0.735	+1.006	.003	.005	3	4
BREAST	PSIP1 →	+2.840	+0.465	<.001	.002	2	5
OVARY	TOX →	+2.576	+0.449	.008	<.001	2	5
OVARY	UBQLN2 →	+0.853	+0.506	.006	.008	2	4
KIDNEY	GOPC →	+0.583	+0.270	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045990 vs WASF1 — LARGE_INTESTINE

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