Negative regulation of striated muscle contraction

Across TCGA patient cohorts, RNA activity of the Negative regulation of striated muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDFY4, RIN3, and STAT5A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of striated muscle contraction activity versus WDFY4 in LSCC (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDFY4 →	+0.448	+0.092	<.001	<.001	3	9
LSCC	RIN3 →	+0.396	+0.087	<.001	<.001	3	8
LSCC	STAT5A →	+0.381	+0.091	<.001	<.001	3	8
LSCC	TRAF3IP3 →	+0.545	+0.071	<.001	<.001	3	8
GBM	VAV1 →	+0.559	+0.077	<.001	<.001	3	8
CCRCC	WAS →	+0.475	+0.079	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045988 vs WDFY4 — LSCC

Explore this scatter interactively →