Negative regulation of striated muscle contraction

Across TCGA cell cohorts, RNA activity of the Negative regulation of striated muscle contraction pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNM2, POU4F3, and VDAC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNM2 grouped by Negative regulation of striated muscle contraction-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DNM2 →	-0.218	-0.139	.006	.007	3	5
PANCREAS	POU4F3 →	-0.148	-0.158	<.001	<.001	2	4
LUNG_SCLC	VDAC1 →	-0.276	-0.164	.004	.004	3	3
OVARY	RERG →	-0.198	-0.156	.001	<.001	3	3
OVARY	ATP5MC2 →	-0.193	-0.156	.005	.004	3	3
OVARY	TDRD5 →	-0.291	-0.166	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNM2 by Negative regulation of striated muscle contraction activity — LARGE_INTESTINE

Explore this box plot interactively →