Negative regulation of nucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of nucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H19, CDA, and HIC1, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of nucleotide metabolic process activity versus H19 in UCS (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	H19 →	+3.692	+0.086	<.001	<.001	3	26
LAML	CDA →	+2.476	+0.097	<.001	<.001	3	22
ACC	HIC1 →	+0.789	+0.037	<.001	<.001	3	18
BLCA	FSTL3 →	+0.965	+0.039	<.001	<.001	3	17
THYM	HSPA12B →	+0.763	+0.047	<.001	<.001	2	17
SARC	ADAMTSL4 →	+0.908	+0.044	.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045980 vs H19 — UCS

Explore this scatter interactively →