Negative regulation of calcium ion-dependent exocytosis

Across TCGA patient cohorts, RNA activity of the Negative regulation of calcium ion-dependent exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT18P39, HNRNPF, and H1-3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion-dependent exocytosis activity versus KRT18P39 in LSCC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KRT18P39 →	-0.208	-0.549	.002	.002	3	4
PDAC	HNRNPF →	-0.188	-0.190	.004	.008	3	4
HNSC	H1-3 →	-0.926	-0.688	.005	.005	3	3
HNSC	MPHOSPH6 →	-0.521	-0.576	.006	.003	3	3
HNSC	SNORD12C →	-0.695	-0.751	.008	.001	3	3
OV	KCNJ2 →	-0.647	-0.826	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045955 vs KRT18P39 — LSCC

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