Negative regulation of calcium ion-dependent exocytosis

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcium ion-dependent exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CKS2, HSPA6, and AKR1B1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CKS2 grouped by Negative regulation of calcium ion-dependent exocytosis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CKS2 →	-0.571	-1.135	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	HSPA6 →	-0.462	-1.160	<.001	.005	3	4
KIDNEY	AKR1B1 →	-2.174	-1.440	<.001	.001	3	4
SOFT_TISSUE	ARRDC2 →	-0.938	-1.249	.004	<.001	3	4
CNS	IK →	-0.573	-1.050	<.001	.001	3	3
CNS	SFXN5 →	-0.922	-0.915	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CKS2 by Negative regulation of calcium ion-dependent exocytosis activity — CNS

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