Negative regulation of calcium ion-dependent exocytosis

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcium ion-dependent exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNAI2, UBE3D, and DRAP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion-dependent exocytosis activity versus GNAI2 in LARGE_INTESTINE (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GNAI2 →	+1.746	+1.532	<.001	<.001	3	6
LUNG_SCLC	UBE3D →	-0.781	-1.056	.001	.004	3	6
LARGE_INTESTINE	DRAP1 →	+0.909	+0.838	.001	.001	3	5
BREAST	PARP3 →	+1.060	+0.668	<.001	.002	3	5
LUNG_SCLC	ATP8A1 →	-1.967	-0.836	.002	.009	3	5
OESOPHAGUS	CAVIN1 →	+2.550	+1.039	.003	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045955 vs GNAI2 — LARGE_INTESTINE

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