Negative regulation of translational initiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP4M1, LAMC2, and RETREG2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AP4M1 grouped by Negative regulation of translational initiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AP4M1 →	-0.815	-0.126	<.001	.002	3	5
LIVER	LAMC2 →	+3.975	+0.318	.002	.001	3	5
LUNG_NSCLC_LUAD	RETREG2 →	-0.422	-0.111	.004	.004	3	4
LUNG_NSCLC_LUAD	ARMC10 →	-0.417	-0.131	.001	<.001	3	4
LUNG_NSCLC_LUAD	BCOR →	-0.567	-0.123	.006	.001	3	4
OESOPHAGUS	SLC45A4 →	+1.131	+0.262	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AP4M1 by Negative regulation of translational initiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →