Positive regulation of steroid metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of steroid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPRY1, KMT5C, and RCC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPRY1 grouped by Positive regulation of steroid metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SPRY1 →	+1.369	+0.281	.005	.008	3	4
LIVER	KMT5C →	+0.871	+0.190	.002	.008	3	4
KIDNEY	RCC1 →	+0.922	+1.305	.003	<.001	2	5
BREAST	NPM3 →	+1.106	+0.128	<.001	.006	3	3
UPPER_AERODIGESTIVE_TRACT	ANGPTL4 →	-2.365	-0.212	.002	.007	3	3
BONE	ZW10 →	+0.921	+1.558	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPRY1 by Positive regulation of steroid metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →