Positive regulation of steroid metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of steroid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA4G, GPRASP1, and GATAD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of steroid metabolic process activity versus SEMA4G in KIDNEY (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SEMA4G →	+1.887	+0.254	.004	<.001	3	5
BONE	GPRASP1 →	+0.752	+0.185	.003	.002	3	5
LUNG_NSCLC_LUAD	GATAD1 →	+0.682	+0.205	.001	.003	2	6
BLOOD_Leukemia	SLC25A13 →	+0.961	+0.126	.009	.003	3	4
LARGE_INTESTINE	SPDYE16 →	+0.179	+0.134	.002	.004	3	4
SOFT_TISSUE	SLFN5 →	-2.678	-0.288	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045940 vs SEMA4G — KIDNEY

Explore this scatter interactively →