Negative regulation of steroid metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of steroid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRPGP15, EEF1A1P14, and EIF3JP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of steroid metabolic process activity versus SNRPGP15 in CCRCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SNRPGP15 →	+0.456	+0.918	<.001	.002	3	3
CCRCC	EEF1A1P14 →	-0.247	-0.560	.001	.008	3	3
LUAD	EIF3JP1 →	-0.053	-1.042	.003	.005	3	3
OV	C10orf120 →	-0.061	-0.797	.007	.003	3	2
UCEC	MIR1249 →	+0.965	+0.555	.009	.005	3	2
GBM	GPR143 →	+0.278	+0.446	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045939 vs SNRPGP15 — CCRCC

Explore this scatter interactively →