Positive regulation of muscle contraction

Across TCGA patient cohorts, RNA activity of the Positive regulation of muscle contraction pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PALM2AKAP2, NUP93_S364, and PNN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle contraction activity versus PALM2AKAP2 in BRCA (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PALM2AKAP2 →	+0.439	+0.024	<.001	.002	3	6
LSCC	NUP93_S364 →	-0.967	-0.078	<.001	<.001	3	6
COAD	PNN →	-0.210	-0.038	<.001	<.001	3	6
LSCC	KAT7_S164 →	-0.409	-0.064	<.001	<.001	3	6
LSCC	ATRX_S598 →	-0.806	-0.068	<.001	<.001	3	5
LSCC	UBA2 →	-0.250	-0.057	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045933 vs PALM2AKAP2 — BRCA

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