Positive regulation of muscle contraction

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle contraction pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENG, DUSP14, and PTGS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ENG grouped by Positive regulation of muscle contraction-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ENG →	-0.213	-0.761	.005	.009	3	5
BREAST	DUSP14 →	-0.145	-0.722	.004	.007	2	5
BREAST	PTGS2 →	-0.070	-0.694	.003	<.001	3	4
LARGE_INTESTINE	HSP90AA1 →	-0.270	-0.870	.006	.004	3	4
KIDNEY	DUOX2 →	-0.225	-1.347	.003	<.001	3	4
KIDNEY	PPAN-P2RY11 →	-0.188	-1.492	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ENG by Positive regulation of muscle contraction activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →