Negative regulation of mitotic cell cycle

Across TCGA cell cohorts, RNA activity of the Negative regulation of mitotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB38, PLAUR, and TSPYL5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB38 grouped by Negative regulation of mitotic cell cycle-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RAB38 →	+1.645	+0.097	.004	.008	2	5
PANCREAS	PLAUR →	+1.707	+0.134	<.001	.001	3	4
BREAST	TSPYL5 →	+2.398	+0.131	<.001	.001	3	4
PANCREAS	CDPF1 →	-0.727	-0.150	.003	<.001	3	4
KIDNEY	RDM1 →	-1.371	-0.181	<.001	<.001	3	4
BLOOD_Leukemia	ARHGEF7 →	+0.981	+0.156	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB38 by Negative regulation of mitotic cell cycle activity — PANCREAS

Explore this box plot interactively →