Positive regulation of growth

Across TCGA cell cohorts, RNA activity of the Positive regulation of growth pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPEB4, MYBL1, and SNX13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of growth activity versus CPEB4 in BLOOD_Leukemia (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CPEB4 →	-1.090	-0.153	.006	.002	3	5
OVARY	MYBL1 →	+1.201	+0.173	.009	.002	3	5
LUNG_SCLC	SNX13 →	-0.603	-0.146	.003	.003	3	5
BLOOD_Myeloma	DET1 →	+0.981	+0.180	.005	<.001	3	5
SOFT_TISSUE	TSPAN5 →	+3.188	+0.265	.001	.001	3	4
BONE	SLC39A7 →	-1.049	-0.313	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045927 vs CPEB4 — BLOOD_Leukemia

Explore this scatter interactively →