Negative regulation of growth

Across TCGA patient cohorts, RNA activity of the Negative regulation of growth pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO, CNRIP1, and PRKG1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of growth activity versus SYNPO in UCEC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYNPO →	+0.457	+0.036	<.001	<.001	3	9
BRCA	CNRIP1 →	+0.683	+0.030	<.001	<.001	3	9
OV	PRKG1 →	+0.601	+0.032	<.001	<.001	3	9
PDAC	RPS2 →	-0.258	-0.028	<.001	<.001	3	9
BRCA	TNS2 →	+0.389	+0.024	<.001	<.001	3	9
PDAC	ITSN1 →	+0.337	+0.024	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045926 vs SYNPO — UCEC

Explore this scatter interactively →