Negative regulation of growth

Across TCGA patient cohorts, RNA activity of the Negative regulation of growth pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENND2C, FAM180A, and HMGB1P26, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of growth activity versus DENND2C in COAD (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DENND2C →	+0.438	+0.485	.001	<.001	3	2
OV	FAM180A →	+1.011	+0.162	.008	.001	3	2
COAD	HMGB1P26 →	-0.106	-0.470	<.001	<.001	3	2
OV	GPR157 →	+1.346	+0.142	.006	.005	3	2
OV	TLR7 →	+1.490	+0.151	.005	.009	3	2
OV	SLIT3-AS1 →	+0.051	+0.173	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045926 vs DENND2C — COAD

Explore this scatter interactively →