Positive regulation of fatty acid metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of fatty acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPT1A, ZNF430, and ZNF286A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fatty acid metabolic process activity versus CPT1A in OVARY (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CPT1A →	+2.324	+1.315	<.001	.001	3	10
BREAST	ZNF430 →	-0.990	-1.046	.001	.005	3	6
STOMACH	ZNF286A →	-1.722	-1.608	.006	.001	3	6
BREAST	SCX →	+0.931	+1.389	.002	<.001	3	5
LUNG_NSCLC_LUSC	POGLUT3 →	-1.677	-2.229	.002	<.001	3	5
STOMACH	HACE1 →	-1.116	-1.220	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045923 vs CPT1A — OVARY

Explore this scatter interactively →