Positive regulation of exocytosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MKS1, CHMP4C, and TMEM182, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MKS1 grouped by Positive regulation of exocytosis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MKS1 →	+0.985	+0.248	<.001	.001	3	3
OESOPHAGUS	CHMP4C →	+1.188	+0.221	.008	<.001	3	3
CNS	TMEM182 →	-0.547	-0.360	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	ILVBL →	+0.919	+0.252	.005	.007	3	2
UPPER_AERODIGESTIVE_TRACT	EZH2 →	+1.223	+0.307	.007	.003	2	3
BLOOD_Leukemia	LRCH1 →	+0.948	+0.167	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MKS1 by Positive regulation of exocytosis activity — LUNG_SCLC

Explore this box plot interactively →