Negative regulation of exocytosis

Across TCGA cell cohorts, RNA activity of the Negative regulation of exocytosis pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS4B, SIAH3, and CBX7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VPS4B grouped by Negative regulation of exocytosis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	VPS4B →	-0.504	-0.617	<.001	.004	3	6
CNS	SIAH3 →	-0.250	-0.978	.002	.002	3	4
BONE	CBX7 →	+0.250	+1.249	.003	.003	3	4
BONE	LMNA →	+0.240	+1.581	.009	<.001	3	4
BLOOD_Lymphoma	SLC47A1 →	-0.298	-0.393	.001	.003	3	4
PANCREAS	RAP1A →	-0.232	-0.941	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VPS4B by Negative regulation of exocytosis activity — BREAST

Explore this box plot interactively →