Negative regulation of complement activation

Across TCGA patient cohorts, RNA activity of the Negative regulation of complement activation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LMCD1, LMCD1_S16, and AHNAK_S819, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of complement activation activity versus LMCD1 in UCEC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LMCD1 →	+0.616	+0.109	.001	.001	3	8
UCEC	LMCD1_S16 →	+0.563	+0.084	.001	.002	3	8
LSCC	AHNAK_S819 →	+0.553	+0.098	.001	.001	3	8
UCEC	CCDC102A_S12 →	+0.812	+0.134	<.001	<.001	3	7
LSCC	AHNAK_S698 →	+0.678	+0.110	<.001	<.001	3	7
UCEC	LMNA →	+0.457	+0.115	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045916 vs LMCD1 — UCEC

Explore this scatter interactively →