Negative regulation of complement activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of complement activation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYY, MRPL34, and SETD7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PYY grouped by Negative regulation of complement activation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PYY →	-0.083	-0.332	.003	.001	3	4
LUNG_SCLC	MRPL34 →	-0.979	-0.347	<.001	<.001	2	4
LUNG_NSCLC_LUAD	SETD7 →	-0.880	-0.413	<.001	.008	3	3
LUNG_NSCLC_LUAD	JAKMIP3 →	-1.071	-0.447	.001	.003	3	3
URINARY_TRACT	CBFB →	-0.793	-0.276	.002	.003	3	3
URINARY_TRACT	TINF2 →	-0.801	-0.276	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PYY by Negative regulation of complement activation activity — STOMACH

Explore this box plot interactively →