Positive regulation of carbohydrate metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of carbohydrate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RTKN_S30, MICOS13, and RGN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of carbohydrate metabolic process activity versus RTKN_S30 in CCRCC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RTKN_S30 →	+0.711	+0.031	<.001	.001	3	5
BRCA	MICOS13 →	+0.264	+0.019	.001	.002	3	4
GBM	RGN →	+0.583	+0.034	.002	.004	3	4
CCRCC	SPART →	+0.151	+0.025	.003	.002	3	4
CCRCC	RAB11FIP5 →	+0.273	+0.030	<.001	<.001	3	4
LSCC	KAT6A_S954 →	-0.555	-0.032	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045913 vs RTKN_S30 — CCRCC

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