Negative regulation of carbohydrate metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of carbohydrate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EFEMP2, VCAN, and EFEMP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of carbohydrate metabolic process activity versus EFEMP2 in UCEC (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EFEMP2 →	+0.590	+0.045	.001	.003	3	8
OV	VCAN →	+1.189	+0.042	.002	.006	3	7
UCEC	EFEMP1 →	+0.702	+0.039	.002	.005	3	7
UCEC	MYLK →	+0.667	+0.040	.001	<.001	3	7
BRCA	SEPTIN11 →	+0.448	+0.029	.001	<.001	2	7
COAD	MPRIP →	+0.259	+0.031	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045912 vs EFEMP2 — UCEC

Explore this scatter interactively →