Negative regulation of carbohydrate metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of carbohydrate metabolic process pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 55 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Negative regulation of carbohydrate metabolic process pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

HNSC, SKCM, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.794	0.645	<.001	121	view →
SKCM	OS	Median	II,III,IV	0.936	0.750	<.001	60	view →
UVM	DFS	Median	All	0.394	0.697	<.001	54	view →
LUAD	OS	Tertile	III,IV	0.663	0.403	.004	27	view →
SCLC	DFS	Tertile	All	0.746	0.486	.009	22	view →
READ	DFS	Quartile	IV	0.233	0.725	.009	18	view →
ESCA	OS	Tertile	III,IV	0.635	0.341	.020	14	view →
ACC	DFS	Median	III,IV	0.606	0.290	.023	14	view →
UCS	DFS	Median	II,III,IV	0.578	0.308	.024	12	view →
CHOL	DFS	Tertile	II,III,IV	0.096	0.501	.023	12	view →
GBM	DFS	Quartile	All	0.188	0.315	.017	9	view →
THCA	DFS	Tertile	III,IV	0.461	0.810	.018	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0045912–HNSC (DFS)

Open the HNSC breakdown →