Negative regulation of carbohydrate metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of carbohydrate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OGFRL1, MRPL21, and BIRC5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OGFRL1 grouped by Negative regulation of carbohydrate metabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	OGFRL1 →	-2.190	-0.370	.005	.002	3	4
UPPER_AERODIGESTIVE_TRACT	MRPL21 →	-1.668	-0.242	<.001	.002	3	4
SKIN	BIRC5 →	-0.595	-0.285	<.001	.004	3	4
LIVER	ASF1B →	-0.818	-0.411	.001	<.001	3	3
LIVER	FAM32A →	-0.656	-0.424	.007	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	EIF4G2 →	-1.200	-0.266	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OGFRL1 by Negative regulation of carbohydrate metabolic process activity — LIVER

Explore this box plot interactively →