Negative regulation of DNA recombination

Across TCGA cell cohorts, RNA activity of the Negative regulation of DNA recombination pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSH2, MIS18BP1, and SUPT16H, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA recombination activity versus MSH2 in BLOOD_Leukemia (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MSH2 →	+1.299	+0.066	<.001	<.001	2	18
BLOOD_Myeloma	MIS18BP1 →	+1.157	+0.086	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	SUPT16H →	+0.945	+0.087	.003	.001	3	15
BONE	RIF1 →	+0.976	+0.066	.002	.008	3	15
BLOOD_Lymphoma	XPO1 →	+0.916	+0.053	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	HELLS →	+1.682	+0.099	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045910 vs MSH2 — BLOOD_Leukemia

Explore this scatter interactively →