Positive regulation of vasoconstriction

Across TCGA patient cohorts, RNA activity of the Positive regulation of vasoconstriction pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UNC13D, SNRNP40, and UTP18, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vasoconstriction activity versus UNC13D in LSCC (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UNC13D →	+0.485	+0.090	<.001	<.001	3	8
GBM	SNRNP40 →	-0.266	-0.072	<.001	<.001	3	7
HNSC	UTP18 →	-0.299	-0.069	<.001	<.001	3	7
HNSC	UTP25 →	-0.423	-0.063	<.001	<.001	3	7
GBM	ADNP →	-0.360	-0.060	<.001	<.001	3	7
UCEC	AZU1 →	+1.026	+0.060	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045907 vs UNC13D — LSCC

Explore this scatter interactively →