Positive regulation of vasoconstriction

Across TCGA cell cohorts, RNA activity of the Positive regulation of vasoconstriction pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB11FIP4, IGFBP3, and IBA57, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vasoconstriction activity versus RAB11FIP4 in BREAST (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RAB11FIP4 →	-1.792	-0.968	<.001	.004	3	4
LUNG_SCLC	IGFBP3 →	+4.201	+1.818	.001	<.001	3	4
BREAST	IBA57 →	-1.514	-1.549	.001	<.001	3	4
STOMACH	MARS2 →	-1.041	-1.562	<.001	.001	3	4
STOMACH	KIF9 →	-1.675	-1.713	.004	<.001	3	4
LUNG_SCLC	SGMS1 →	+1.166	+1.932	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045907 vs RAB11FIP4 — BREAST

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