Negative regulation of vasoconstriction

Across TCGA patient cohorts, RNA activity of the Negative regulation of vasoconstriction pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MMP2, LAMA3, and PALM2AKAP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of vasoconstriction activity versus MMP2 in BRCA (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MMP2 →	+0.823	+0.073	<.001	<.001	3	8
HNSC	LAMA3 →	+0.860	+0.065	<.001	.002	3	7
BRCA	PALM2AKAP2 →	+0.701	+0.074	<.001	<.001	3	7
BRCA	ZYX →	+0.440	+0.090	<.001	<.001	3	7
BRCA	CSPG4 →	+0.561	+0.073	<.001	<.001	3	7
BRCA	PARVA →	+0.608	+0.070	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045906 vs MMP2 — BRCA

Explore this scatter interactively →