Negative regulation of smoothened signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of smoothened signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CISD2, SIRT1, and MUC5B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of smoothened signaling pathway activity versus CISD2 in LUAD (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CISD2 →	-0.286	-0.625	.001	<.001	3	3
LUAD	SIRT1 →	-0.239	-0.359	.002	.004	3	3
COAD	MUC5B →	-1.417	-0.732	<.001	<.001	3	3
COAD	SSUH2 →	+0.762	+0.717	<.001	<.001	3	3
COAD	CXCL17 →	-0.854	-0.581	<.001	<.001	3	3
GBM	SNHG18 →	+0.940	+0.173	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045879 vs CISD2 — LUAD

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