Negative regulation of smoothened signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of smoothened signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C12orf57, MTMR10, and ARHGAP23, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C12orf57 grouped by Negative regulation of smoothened signaling pathway-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	C12orf57 →	-0.948	-0.173	.002	<.001	3	4
LIVER	MTMR10 →	+0.931	+0.175	.004	.006	3	4
BREAST	ARHGAP23 →	+1.389	+0.130	.008	.006	3	4
KIDNEY	AP4S1 →	+1.014	+0.198	.004	.002	3	3
KIDNEY	ZFAND2B →	-0.617	-0.185	.002	.005	3	3
URINARY_TRACT	NIT2 →	+0.751	+0.193	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C12orf57 by Negative regulation of smoothened signaling pathway activity — OESOPHAGUS

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