Negative regulation of smoothened signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of smoothened signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPN3, EIF4G3, and NBEAL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of smoothened signaling pathway activity versus EPN3 in BREAST (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EPN3 →	-3.360	-0.152	<.001	.008	3	6
LUNG_NSCLC_LUSC	EIF4G3 →	+0.802	+0.404	.002	.004	3	6
BREAST	NBEAL2 →	-0.984	-0.124	.005	.005	3	5
OVARY	SNAPC1 →	+1.925	+0.201	<.001	.001	3	5
BONE	RRM1 →	+1.021	+0.292	.004	.001	3	5
URINARY_TRACT	SLC35G2 →	+2.166	+0.374	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045879 vs EPN3 — BREAST

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