Negative regulation of proteolysis

Across TCGA cell cohorts, RNA activity of the Negative regulation of proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM76A, ZNF26, and PLCB3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM76A grouped by Negative regulation of proteolysis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FAM76A →	-0.532	-0.876	.002	.001	3	5
BLOOD_Myeloma	ZNF26 →	-0.788	-1.290	.005	<.001	3	4
OESOPHAGUS	PLCB3 →	-0.811	-1.131	.003	.004	3	4
CNS	SLC35E4 →	-0.841	-0.920	.009	.002	3	4
CNS	SYNPO →	-1.570	-0.925	.003	.003	3	4
CNS	AGPS →	-0.808	-1.052	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM76A by Negative regulation of proteolysis activity — SKIN

Explore this box plot interactively →